B. Paul Morgan

The paper identifies placental microthrombi as structures that link coagulation and complement to regulate placental vascular development, showing that platelet activation via PAR4 is necessary for localized complement activation.

This study uses single-nucleus RNA sequencing to map complement gene expression in human hippocampus, identifying cell-type-specific patterns and changes in Alzheimer's disease.

This study shows that wild-type bone marrow cells can restore macrophage populations and reverse developmental defects in Csf1rko rats, but not in the brain.

This study shows that complement components C3 and C3aR differentially affect innate anxiety and conditioned fear in mice, linking complement pathways to psychiatric disorder risk.

This study shows Abi3 is essential for microglial morphology, distribution, and tissue surveillance in vivo, linking it to Alzheimer's disease risk.

This paper creates a mouse model expressing human CR1 and CR2 variants to study their role in disease.

The paper uses a novel gene-based analysis approach to identify three novel genes associated with Alzheimer’s disease using genome-wide association data.