SETD3 ACTIN HISTIDINE METHYLTRANSFERASE REGULATES INTESTINAL EPITHELIAL BARRIER INTEGRITY AND MUCOSAL INFLAMMATION
Prasath Manogaran, Nayden G. Naydenov, Susana Lechuga, Naseer Sangwan, Andrew Deng, Ajay H. Zalavadia, Andrei I. Ivanov
This study shows that SETD3 methylates actin, enhancing F-actin polymerization and protecting intestinal epithelial barrier integrity, and its loss worsens inflammation and permeability.
bioRxiv · Oct 5, 2026 · PreprintCell Biology