A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells
Ian C. Tobias, Sakthi D. Moorthy, Virlana M. Shchuka, Lida Langroudi, Mariia Cherednychenko, Zoe E. Gillespie, Andrew G Duncan, Ruxiao Tian, Natalia A Gajewska, Raphaël B. Di Roberto, Jennifer A. Mitchell
This study identifies a cis-regulatory enhancer cluster, SRR2-18, that regulates Sox2 transcription in mouse neural stem/progenitor cells, affecting their regional identity and differentiation into posterior neural fates.
G3 Genes Genomes Genetics · Jan 24, 2025Peer-reviewedGenetics