Virlana M. Shchuka

This study identifies a cis-regulatory enhancer cluster, SRR2-18, that regulates Sox2 transcription in mouse neural stem/progenitor cells, affecting their regional identity and differentiation into posterior neural fates.

This study shows SOX4 regulates labor-associated gene promoters in myometrial cells through interactions with AP-1 factors, with varying effects on different promoters.

The paper identifies MYB and ELF3 as transcription factors that differentially regulate labor-inducing gene expression in myometrial cells, with opposing effects on promoter activity.

The paper shows that transcriptional control and chromatin architecture at the Sox2 locus are decoupled, with distinct regulatory mechanisms.

The paper identifies epigenetic activation of contractility-driving genes in the mouse myometrium before labor onset, revealing early H3K27ac enrichment and transcriptional changes during active labor.