Author

Ruxiao Tian

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Jennifer A. MitchelliD· 2 shared Sakthi D. MoorthyiD· 2 shared Alan M MosesiD· 1 shared Andrew G Duncan· 1 shared Andrew G. Duncan· 1 shared Gurdeep SinghiD· 1 shared Ian C. TobiasiD· 1 shared Lida LangroudiiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Jennifer A. MitchellORCID

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2 papers

Recent·Most cited

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells

Ian C. Tobias, Sakthi D. Moorthy, Virlana M. Shchuka, Lida Langroudi, Mariia Cherednychenko, Zoe E. Gillespie, Andrew G Duncan, Ruxiao Tian, Natalia A Gajewska, Raphaël B. Di Roberto, Jennifer A. Mitchell

This study identifies a cis-regulatory enhancer cluster, SRR2-18, that regulates Sox2 transcription in mouse neural stem/progenitor cells, affecting their regional identity and differentiation into posterior neural fates.

G3 Genes Genomes Genetics · Jan 24, 2025Peer-reviewedGenetics

A flexible repertoire of transcription factor binding sites and diversity threshold determines enhancer activity in embryonic stem cells

Gurdeep Singh, Shanelle Mullany, Sakthi D. Moorthy, Richard Zhang, Tahmid Mehdi, Ruxiao Tian, Andrew G. Duncan, Alan M Moses, Jennifer A. Mitchell

The paper identifies a diversity threshold of transcription factor binding sites (TFBS) required for enhancer activity in embryonic stem cells, showing that a diverse set of TFBS can replace optimized regulatory sequences.

Genome Research · Apr 1, 2021Peer-reviewedGenomics