MX2 Mediates Collapse of the HIV-1 Capsid
Andrew Goodale, Szu‐Wei Huang, Nathalia Almeida, Dave J. Williamson, Nikoloz Shkriabai, Gilberto Betancor, Luis Apolonia, Frank DiMaio, Sergi Padilla‐Parra, Mamuka Kvaratskhelia, Julien R. C. Bergeron, Michael H. Malim
This study identifies the minimal MX2 region required for HIV-1 restriction and shows that MX2 binding disrupts the capsid lattice, leading to premature fragmentation and preventing viral nuclear import.
bioRxiv · May 8, 2026 · PreprintMicrobiology