Michael H. Malim

Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses

Gag proteolysis drives HIV-1 envelope conformational closure through the gp41 cytoplasmic tail

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

MX2 Mediates Collapse of the HIV-1 Capsid

This study identifies the minimal MX2 region required for HIV-1 restriction and shows that MX2 binding disrupts the capsid lattice, leading to premature fragmentation and preventing viral nuclear import.

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections

The paper identifies diverse spike haplotypes in persistent SARS-CoV-2 infections that show immune escape mechanisms similar to variants of concern.

Oncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity

This paper shows that oncolytic Reovirus can eliminate SARS-CoV-2 in lung cells without causing toxicity by enhancing innate antiviral responses.

Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition

The paper examines the association between adipose tissue ACE2 expression and cardio-metabolic risk factors, finding lower ACE2 levels linked to T2D, obesity, and inflammation-related cell type changes.