Sergi Padilla‐Parra

Gag proteolysis drives HIV-1 envelope conformational closure through the gp41 cytoplasmic tail

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

Structural analysis reveals high-order Nipah Virus Fusion Protein assemblies and interactions with neutralising nanobodies

The paper uses cryo-electron tomography to study NiV fusion protein assemblies and shows nanobodies block inter-trimer interactions, inhibiting viral entry.

MX2 Mediates Collapse of the HIV-1 Capsid

This study identifies the minimal MX2 region required for HIV-1 restriction and shows that MX2 binding disrupts the capsid lattice, leading to premature fragmentation and preventing viral nuclear import.

Mesoscale Transport of Enveloped Viruses

This study investigates how spike protein dynamics affect enveloped virus mobility using mesoscopic models and experimental validation.

Early HIV-1 maturation drives Env clustering and fusion competence

This study shows that early HIV-1 maturation steps, specifically partial Gag cleavage, promote Env clustering and fusion competence by reorganizing the membrane-proximal lattice.

Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.

The RNA-binding proteins CELF1 and ELAVL1 cooperatively control alternative splicing

This study identifies CELF1 and ELAVL1 as cooperative regulators of alternative splicing, showing additive effects and a role in cancer prognosis.

Orthogonal fluorescent chemogenetic reporters for multicolor imaging

The paper introduces two spectrally orthogonal chemogenetic tags for multicolor live cell imaging, enabling detection of early cell cycles and protein interactions.