Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit
Erin N. Sanders, Hsuan-Te Sun, Saman Tabatabaee, Charles F. Lang, Sebastian Gerhard Van Dijk, Yu‐Han Su, Andrew Labofl, Javeria Idris, Li He, Marco Marchefli, Shicong Xie, Lucy Erin O’Brien
This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.
bioRxiv · Dec 29, 2024 · PreprintDevelopmental Biology