Marco Marchetti

Dysregulated neutrophil extracellular trap formation is a novel driver of clonogenicity and therapeutic vulnerability in CMML

This study shows that dysregulated neutrophil extracellular trap formation drives clonogenicity in CMML and can be inhibited by nNIF and other agents.

Mating and ecdysone signaling modify growth, metabolism, and digestive efficiency in the female Drosophila gut

This study shows mating in Drosophila females alters gut metabolism, digestive efficiency, and gene expression, with ecdysone signaling playing a key role in these changes.

Extracellular matrix and cytoskeletal reverse remodeling pathways are key drivers of myocardial recovery following left ventricular assist device therapy

This study identifies DNA methylation and gene expression changes in heart failure patients before and after LVAD therapy, linking extracellular matrix and cytoskeletal remodeling to myocardial recovery.

Schistosoma mansoni antigen induced innate immune memory features mitochondrial biogenesis and can be inhibited by ovarian produced hormones

This study shows that Schistosoma mansoni antigens induce innate immune training in males but not females, which can be inhibited by ovarian hormones and involves mitochondrial biogenesis.

Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit

This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.

Bwa, an ortholog of alkaline ceramidase-ACER2, promotes intestinal stem cell proliferation through pro-inflammatory cytokine signaling in Drosophila melanogaster

This study identifies Bwa as a regulator of intestinal stem cell proliferation in Drosophila through pro-inflammatory cytokine signaling, linking sphingolipid metabolism to gut homeostasis.