Shicong Xie

Tissue geometry patterns epidermal stem cell fate in murine interfollicular skin

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

Synthetic genome expansion reveals a transcriptional constraint on genome size

This study expands the yeast genome with non-coding DNA and finds it reduces growth rate and endogenous mRNA concentration without affecting translation.

A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription

The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size

This study shows that cell size autonomously regulates the G1/S transition in mammalian epidermal stem cells, independent of extracellular signals.

Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit

This study shows that organ injury accelerates stem cell differentiation by altering a Notch-Delta lateral inhibition circuit, reducing feedback delays and increasing Delta ligand levels.

Reversible disruption of specific transcription factor-DNA interactions using CRISPR/Cas9

This study develops a CRISPR/Cas9 method to reversibly disrupt specific transcription factor-DNA interactions and assess their functional impact on gene expression and cell division.