Aging disrupts spatiotemporal coordination in the cycling murine ovary
Tammy C. T. Lan, Alison Kochersberger, Ruth Raichur, Sophia Szady, Hien Tran, Radiana Simeonova, Ashley Helmuth, Andrew Minagar, Maria José Orozco Fuentes, Vipin Kumar, Giovanni J. Marrero, Irving Barrera, Sarah M. Mangiameli, Alex K. Shalek, Pardis Christine Sabeti, , Hattie Chung
This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.
Nature Aging · Jun 17, 2026Peer-reviewedGenomics