Author

Sarah M. Mangiameli

Broad InstituteORCID 0000-0002-6799-3436Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Assay:ATAC-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Fei CheniD· 4 shared Haiqi CheniD· 2 shared Alex K. ShalekiD· 1 shared Alison KochersbergeriD· 1 shared Andrew EarliD· 1 shared Andrew Minagar· 1 shared Anna GrekaiD· 1 shared Ashley HelmuthiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersGenomics

Fei ChenORCID

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Author profile →

4 papers

Recent·Most cited

Aging disrupts spatiotemporal coordination in the cycling murine ovary

Tammy C. T. Lan, Alison Kochersberger, Ruth Raichur, Sophia Szady, Hien Tran, Radiana Simeonova, Ashley Helmuth, Andrew Minagar, Maria José Orozco Fuentes, Vipin Kumar, Giovanni J. Marrero, Irving Barrera, Sarah M. Mangiameli, Alex K. Shalek, Pardis Christine Sabeti, , Hattie Chung

This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.

Nature Aging · Jun 17, 2026Peer-reviewedGenomics

Subcellular Level Spatial Transcriptomics with PHOTON

Shreya Rajachandran, Qianlan Xu, Qiqi Cao, Xin Zhang, Fei Chen, Sarah M. Mangiameli, Haiqi Chen

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

Nature Communications · May 14, 2025Peer-reviewedGenomics

Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution

Sarah M. Mangiameli, Haiqi Chen, Andrew Earl, Julie A. Dobkin, Daniel Lesman, Jason Daniel Buenrostro, Fei Chen

The paper introduces Photoselective Sequencing, a method to measure genomic data with subcellular resolution, and applies it to study chromatin accessibility and nuclear positioning in mouse brain cells.

Nature Methods · Apr 27, 2023Peer-reviewedGenomics

HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes

Jamie L. Marshall, Benjamin R. Doughty, Vidya Subramanian, Philine Guckelberger, Qingbo S. Wang, Linlin M. Chen, Samuel G. Rodriques, Kaite Zhang, Charles P. Fulco, Joseph Nasser, Elizabeth J. Grinkevich, Teia Noel, Sarah M. Mangiameli, Drew T. Bergman, Anna Greka, , J Engreitz

HyPR-seq sensitively quantifies up to 100 chosen genes in single cells, achieving high sensitivity for individual transcripts and reducing costs compared to whole-transcriptome scRNA-seq.

Proceedings of the National Academy of Sciences · Dec 21, 2020Peer-reviewedGenomics