Direct measurement of sub-kilobase chromatin structure reveals that linker histone H1 broadly compacts chromatin, with differential impact amongst epigenetic states
Hera Canaj, Irene Duba, Andrés Mansisidor, Andrew Scortea, Ryan Johnson, Hugo Borges Pinto, Arnold Ou, Nicole Pagane, Juhee Pae, Dmitry V. Fyodorov, Arthur I. Skoultchi, Viviana I. Risca
The paper directly measures sub-kilobase chromatin structure using RICC-seq 2.0 and finds that linker histone H1 broadly compacts chromatin, with differential effects on gene expression and epigenetic states.
bioRxiv · Dec 23, 2025 · PreprintGenomics