Arnold Ou

This paper introduces CAD-C, a new chromatin conformation capture method that improves resolution and efficiency over existing techniques like Micro-C and Hi-C.

The paper directly measures sub-kilobase chromatin structure using RICC-seq 2.0 and finds that linker histone H1 broadly compacts chromatin, with differential effects on gene expression and epigenetic states.

This study compares the SASP and transcriptional profiles induced by CDK4/6 inhibitors and DNA damage, revealing delayed NF-κB activation in CDK4/6i.