Hera Canaj

This paper introduces CAD-C, a new chromatin conformation capture method that improves resolution and efficiency over existing techniques like Micro-C and Hi-C.

The paper directly measures sub-kilobase chromatin structure using RICC-seq 2.0 and finds that linker histone H1 broadly compacts chromatin, with differential effects on gene expression and epigenetic states.

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.