High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization
Sophia R. Meyer, Max A. Garcia, Neil Zhao, Samantha F. Boisvert, Matthew McConnachie, Charles J. Zhang, Benjamin S. Halligan, Andrew M. Tidball, Andrew Tucker, Josepha Kaganove, Jesse W. Wotring, Joel A. Yates, Diana Flores, Robert J. Fontana, Jonathan Z. Sexton
This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.
bioRxiv · Oct 4, 2026 · PreprintPharmacology & Toxicology