Author

Benjamin S. Halligan

Michigan MedicineORCID 0000-0002-7587-2597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:machine learning (classical)· 2 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Jesse W. WotringiD· 2 shared Jonathan Z. SextoniD· 2 shared Samantha F. BoisvertiD· 2 shared Andrew M. TidballiD· 1 shared Andrew Tucker· 1 shared Andrew W. TaiiD· 1 shared Charles J. ZhangiD· 1 shared Daniel Macedo de Melo JorgeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Jesse W. WotringORCID

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2 papers

Recent·Most cited

A High-Content Pseudotime Framework for Morphological Profiling of Dengue Virus Inhibitors from a Drug-Repurposing Library

Jillian G. Hoffstadt, Samantha F. Boisvert, Jesse W. Wotring, Samuel S. Porter, Benjamin S. Halligan, Daniel Macedo de Melo Jorge, Andrew W. Tai, Jonathan Z. Sexton, Matthew J. O’Meara

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

bioRxiv · Oct 9, 2026 · PreprintCell Biology

High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization

Sophia R. Meyer, Max A. Garcia, Neil Zhao, Samantha F. Boisvert, Matthew McConnachie, Charles J. Zhang, Benjamin S. Halligan, Andrew M. Tidball, Andrew Tucker, Josepha Kaganove, Jesse W. Wotring, Joel A. Yates, Diana Flores, Robert J. Fontana, Jonathan Z. Sexton

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

bioRxiv · Oct 4, 2026 · PreprintPharmacology & Toxicology