Targeted epigenetic repression of oncogenic transcription factors via CRISPR/dCas9 locus-specific silencing
Shahama Taifour, Christopher Wallis, Edina Wang, Eleanor Woodward, Ash W J Tie, Charlene Babra Waryah, Larissa Dymond, Andrew Woo, Peter J. Houghton, K Swaminathan Iyer, Marck Nörret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort
This paper develops a non-viral CRISPR/dCas9-KRAB system for epigenetic silencing of oncogenic transcription factors in Ewing Sarcoma, showing effective tumor suppression in cell line and patient-derived xenograft models.
bioRxiv · Jun 27, 2026 · PreprintGenomics