Peter J. Houghton

This paper develops a non-viral CRISPR/dCas9-KRAB system for epigenetic silencing of oncogenic transcription factors in Ewing Sarcoma, showing effective tumor suppression in cell line and patient-derived xenograft models.

DepLink links genetic and pharmacologic dependencies in cancer by integrating CRISPR, pharmacologic, and expression data through an R Shiny app.

PCAT is a portal for pediatric cancer PDX models and associated genomic data, providing clinical, molecular, and preclinical testing information for 324 models and 79 therapeutic agents.

This paper genomically characterizes 261 pediatric cancer patient-derived xenograft models to guide rational clinical trial design and drug development.