Structure-guided design and development of cyclic peptide allosteric activators of Polycomb Repressive Complex 2
Yasuaki Tokodai, Mark N. Matyas, Azumi Ishigamori, Erin O’Connor, Angel Zhang, Sora Yamazaki, Tsunehide Hiraki, Noah Lohar, Liqi Yao, Ryan C. Stoner, Luis E. Paez-Beltran, Kayoko Kanamitsu, Noriko Nakaya, Satoshi Ichikawa, Justin Brumbaugh, , Fumika Yakushiji
The paper designs a cyclic peptide that activates PRC2, leading to increased H3K27 trimethylation and improved stability in mice.
bioRxiv · Jun 26, 2025 · PreprintBiochemistry