BiochemistrybioRxivPreprint
Structure-guided design and development of cyclic peptide allosteric activators of Polycomb Repressive Complex 2
Yasuaki Tokodai, Mark N. Matyas, Azumi Ishigamori…·Fumika Yakushiji
The paper designs a cyclic peptide that activates PRC2, leading to increased H3K27 trimethylation and improved stability in mice.
DOI 10.1101/2025.06.26.661818