Angela Michela De Stasi

This study shows that early postnatal fluoxetine exposure alters adult prefrontal cortex circuits via 5-HT7 receptors, affecting neuronal firing patterns and contributing to depressive and anxiety-like behaviors.

The paper identifies specific inhibitory circuit alterations in the prefrontal cortex of a Down syndrome mouse model, linking them to cognitive dysfunction.

The paper shows that plasticity of inhibitory synapses onto layer 5 pyramidal neurons modulates excitation-inhibition ratios, neuronal gain, and information transfer across cortical layers.