Joana Lourenço

This study shows that early postnatal fluoxetine exposure alters adult prefrontal cortex circuits via 5-HT7 receptors, affecting neuronal firing patterns and contributing to depressive and anxiety-like behaviors.

The paper identifies distinct dendritic integration strategies in two types of cortical interneurons that lead to different temporal dynamics of inhibition.

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

The paper identifies the molecular signature and connectivity specificity of Martinotti cell inhibitory circuits in the mouse barrel cortex, revealing target-specific synaptic properties and the role of 5-GABAARs in cognitive functions.

The paper identifies specific inhibitory circuit alterations in the prefrontal cortex of a Down syndrome mouse model, linking them to cognitive dysfunction.

The paper shows that plasticity of inhibitory synapses onto layer 5 pyramidal neurons modulates excitation-inhibition ratios, neuronal gain, and information transfer across cortical layers.

The paper investigates autaptic self-connectivity in neocortical PV interneurons and finds it significantly contributes to perisomatic inhibition and synchronization with gamma-oscillations.