Progranulin deficiency aggravates aging-induced vascular injury
Renata de Azevedo Melo Luvizotto, André Ferreira do Nascimento, Gustavo Félix Pimenta, Rafael Menezes da Costa, Shubhnita Singh, Juliano V Alves, Wanessa M.C. Awata, Angela Russ, Adeyeye I. Haastrup, Rolando A. Cuevas, Parya Behzadi, Cynthia St. Hilaire, Justin T. Roberts, Ariane Bruder‐Nascimento, Thiago B Bruder-Nascimento
This study shows that progranulin deficiency worsens age-related vascular damage in mice, affecting endothelial function and vascular remodeling.
bioRxiv · Nov 25, 2025 · PreprintCell Biology