Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy S. Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen Brennand, Joseph R. Calabrese, William H Coryell, M.A. Frye, Fred H. Gage, Elliot S. Gershon, , Michael J. McCarthy
This study shows that bipolar disorder patient-derived neurons exhibit circadian rhythm abnormalities, with lithium non-responders showing more severe deficits that can be partially reversed by temperature entrainment.
Biological Psychiatry · Apr 27, 2021Peer-reviewedNeuroscience