AP-1 Primes Transcriptional Noise-Led Cancer Treatment Adaptation Through KDM5 Chromatin Rewiring
Alejandro Allo Anido, Cecilia Roux, Ayeh Sadat Sadr, Siân Hamer, Emilia Chen, Abigail Shea, Christie English, Charlotte Butterworth, Harvey Che, Angella Bellini, Birgit Geoerger, Gudrun Schleiermacher, Louis Chesler, Michael David Morgan, Alejandra Bruna
The paper identifies transcriptional noise as a driver of cancer treatment adaptation through AP-1 and KDM5-mediated chromatin rewiring in neuroblastoma and hepatoblastoma.
bioRxiv · Oct 13, 2025 · PreprintCancer Biology