Birgit Geoerger

This paper identifies M30-E05, an engineered flavonoid that disrupts the AIF/CHCHD4 mitochondrial complex, reducing cancer cell viability and tumor growth in xenograft models.

This study identifies a metabolic vulnerability in osteosarcoma by combining AIF/CHCHD4 inhibition and GLS1 suppression, showing synergy between mitoxantrone and telaglenastat in vitro and in vivo.

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

The paper identifies transcriptional noise as a driver of cancer treatment adaptation through AP-1 and KDM5-mediated chromatin rewiring in neuroblastoma and hepatoblastoma.

This paper identifies DiPRO1 as a regulator of myoblast differentiation and mesenchymal tumor suppression through epigenetic and transcriptional mechanisms, showing its potential as a therapeutic target.

CellsFromSpace is a reference-free tool for deconvolving and annotating spatial transcriptomic data, outperforming existing methods in accuracy and speed across multiple technologies.

This study identifies three modes of plasticity in neuroblastoma that shape tumour evolution under selective pressures and therapy resistance.