Single-cell, multi-region profiling of the macaque brain across the lifespan
Wei Yang, Kirsty Watkins, Alex R. DeCasien, Mary B. O’Neill, Martin O. Bohlen, Diana R. O’Day, Madeleine Duran, Chengxiang Qiu, A. N. Meleshko, Anh Vo, Melia Menke, Diego Calderon, Jérôme Sallet, James P. Higham, Melween I. Martínez, , Noah Snyder‐Mackler
This study profiles 5.3 million cells from 55 rhesus macaques across their lifespan to map age-related changes in brain cell types and identify molecular signatures linked to aging and Alzheimer's disease.
bioRxiv · Oct 31, 2025 · PreprintNeuroscience