Mary B. O’Neill

Single-cell, multi-region profiling of the macaque brain across the lifespan

This study profiles 5.3 million cells from 55 rhesus macaques across their lifespan to map age-related changes in brain cell types and identify molecular signatures linked to aging and Alzheimer's disease.

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

The paper describes a method to generate human embryo-like structures by pre-patterning stem cells and mixing them, resulting in models with extended anterior-posterior organization and neural features.

Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

The paper identifies environmental and genetic factors influencing population differences in SARS-CoV-2 immune responses using single-cell RNA-sequencing data.

Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunity

The paper investigates monocyte subset heterogeneity and its impact on influenza virus susceptibility across populations, revealing differences in transcriptional responses and infection resistance between African and European ancestry individuals.

A Complex Evolutionary History for the Disease Susceptibility CDHR3 Locus

The paper investigates the evolutionary history of the CDHR3 locus, finding that the protective variant against RV-C and asthma has been subject to selection in recent human evolution, though not as a classical selective sweep.