Leveraging death of drug-sensitive cancer cells to promote immune-mediated bystander killing of subclones of drug-resistant tumor cells
Mona Tomaschko, KangBo Ng, Christopher Moore, Claire E. Pillsbury, Sareena Rana, James Campbell, Saptaparna Mukherjee, Ania Mikolajczak, Panayiotis Anastasiou, Andrea de Castro, Alicia Alonso de la Vega, Sophie de Carné Trécesson, Nathan W. Goehring, Míriam Molina‐Arcas, Julian Downward
This study shows that targeting drug-sensitive cancer cells with G12Ci inhibitors and combining it with immune therapies can eliminate drug-resistant subclones through immune-mediated bystander killing.
bioRxiv · Oct 27, 2025 · PreprintCancer Biology