Nathan W. Goehring

This paper shows that a minimal mechanical model of an actomyosin network can spontaneously polarize and move through balanced contractility and adhesion, without external cues or complex signaling.

The paper shows that PAR-3 proteins form stable clusters during anoxia in C. elegens embryos, preserving polarity information for rapid reactivation after metabolic arrest.

This paper shows that cell cycle oscillations in a polarity network allow cells to switch polarity states in response to morphogenetic cues by modulating feedback and stability.

This study shows that targeting drug-sensitive cancer cells with G12Ci inhibitors and combining it with immune therapies can eliminate drug-resistant subclones through immune-mediated bystander killing.

The paper shows that nonlinear spatial cue readout in C. elegans zygotes ensures robust asymmetric cell division despite input variation.