FGL-1 binding to LAG-3 inhibits T cell activation via disruption of CD28 and TCR signaling
Samantha Nyovanie, Anika Hashem, Evgeny Kanshin, Nicolas Oltean, Beatrix M. Ueberheide, Y. Patskovsky, Michelle Krogsgaard
This study shows FGL-1 binding to LAG-3 inhibits T cell activation by disrupting CD28 and TCR signaling through Lck mislocalization and reduced phosphorylation.
bioRxiv · Aug 5, 2025 · PreprintImmunology