BK channel gain-of-function disrupts limb control by suppressing neurotransmission during a critical developmental window
Simon A. Lowe, Abigail D. Wilson, Gabriel Aughey, Animesh Banarjee, Talya Goble, Nell Simon-Batsford, Angelina Sanderson, Patrick Krätschmer, Maryam Balogun, Hao Gao, Sherry Shiying Aw, James E.C. Jepson
This study shows that gain-of-function BK channel mutations disrupt limb control in fruit flies by altering neuronal development during a critical period, not by affecting mature circuits.
bioRxiv · Sep 20, 2023 · PreprintNeuroscience