Author

Patrick Krätschmer

UCL Queen Square Institute of Neurology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:Drosophila· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Assay:electronic health records· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

James E.C. JepsoniD· 5 shared Simon A. LoweiD· 3 shared Angélique LamazeiD· 2 shared Ko‐Fan CheniD· 2 shared Abigail D. WilsoniD· 1 shared Alan Michael PittmaniD· 1 shared Angelina Sanderson· 1 shared Animesh Banarjee· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersNeuroscience

James E.C. JepsonORCID

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Author profile →

5 papers

Recent·Most cited

BK channel gain-of-function disrupts limb control by suppressing neurotransmission during a critical developmental window

Simon A. Lowe, Abigail D. Wilson, Gabriel Aughey, Animesh Banarjee, Talya Goble, Nell Simon-Batsford, Angelina Sanderson, Patrick Krätschmer, Maryam Balogun, Hao Gao, Sherry Shiying Aw, James E.C. Jepson

This study shows that gain-of-function BK channel mutations disrupt limb control in fruit flies by altering neuronal development during a critical period, not by affecting mature circuits.

bioRxiv · Sep 20, 2023 · PreprintNeuroscience

A knock-in Drosophila model supports a conserved link between potassium channelopathy and involuntary movement

Patrick Krätschmer, Simon A. Lowe, Edgar Buhl, Ko‐Fan Chen, Dimitri Michael Kullmann, Alan Michael Pittman, James J. L. Hodge, James E.C. Jepson

This study creates a Drosophila model with a hSlo1 D434G mutation, showing motor dysfunction and altered action potentials linked to BK channel gain-of-function.

Movement Disorders · Jan 15, 2021Peer-reviewedNeuroscience

Altered synaptic plasticity and central pattern generator dysfunction in a Drosophila model of PNKD3 paroxysmal dyskinesia

Simon A. Lowe, Patrick Krätschmer, James E.C. Jepson

This study examines how a BK channel mutation affects synaptic plasticity and motor circuits in Drosophila larvae, finding altered neurotransmitter release and CPG dysfunction.

bioRxiv · Feb 20, 2020 · PreprintNeuroscience

A sleep-regulatory circuit integrating circadian, homeostatic and environmental information in Drosophila

Angélique Lamaze, Patrick Krätschmer, James E.C. Jepson

This study identifies a circuit in Drosophila where DN1p neurons integrate circadian, homeostatic, and environmental cues to regulate sleep onset.

bioRxiv · Jan 22, 2018 · PreprintNeuroscience

The Drosophila dystonia gene homolog Neurocalcin facilitates sleep by inhibiting a movement-promoting neural network

Ko‐Fan Chen, Angélique Lamaze, Patrick Krätschmer, James E.C. Jepson

This study identifies Neurocalcin's role in promoting sleep by inhibiting a movement-promoting neural network in Drosophila.

bioRxiv · Nov 13, 2017 · PreprintNeuroscience