Metabolic adaptations underpin resistance to histone acetyltransferase inhibition
Timothy R. Bishop, Chitra Subramanian, Eric M. Bilotta, Leopold Garnar-Wortzel, Anissa R. Ramos, Yuxiang Zhang, Joshua N. Asiaban, Christopher J. Ott, Charles O. Rock, Michael A. Erb
This study identifies CoA metabolism dysregulation as a mechanism of resistance to HAT inhibitors in AML, revealing a potential class-wide vulnerability for anti-cancer therapies targeting HATs.
Nature Chemical Biology · May 1, 2023Peer-reviewedMolecular Biology