Molecular BiologyNature Chemical BiologyPeer-reviewed
Metabolic adaptations underpin resistance to histone acetyltransferase inhibition
Timothy R. Bishop, Chitra Subramanian, Eric M. Bilotta…·Michael A. Erb
This study identifies CoA metabolism dysregulation as a mechanism of resistance to HAT inhibitors in AML, revealing a potential class-wide vulnerability for anti-cancer therapies targeting HATs.
39 citations