Leopold Garnar-Wortzel

The paper introduces RyboCypher, a platform that maps the dark transcriptome to unannotated peptides, identifying cryptic proteins in cancer cell lines, tumors, and healthy tissues.

This study investigates the effects of ENL YEATS domain inhibitors in leukemia models, finding that suppression of ENL target genes is not sufficient to explain their anti-leukemia effects.

This study identifies CoA metabolism dysregulation as a mechanism of resistance to HAT inhibitors in AML, revealing a potential class-wide vulnerability for anti-cancer therapies targeting HATs.