Timothy R. Bishop

This study uses high-throughput chemistry to discover chemical inducers of proximity by modifying pre-existing ligands and screening for degrader activity.

This study investigates the effects of ENL YEATS domain inhibitors in leukemia models, finding that suppression of ENL target genes is not sufficient to explain their anti-leukemia effects.

This study identifies CoA metabolism dysregulation as a mechanism of resistance to HAT inhibitors in AML, revealing a potential class-wide vulnerability for anti-cancer therapies targeting HATs.

The paper identifies three classes of enhancers regulated by Bicoid and Orthodenticle in Drosophila embryos, revealing a feed-forward relay mechanism that coordinates gene expression timing.