Author

Charles O. Rock

St. Jude Children's Research HospitalORCID 0000-0001-8648-4189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Chitra SubramanianiD· 2 shared Anissa R. Ramos· 1 shared Christopher D. RadkaiD· 1 shared Christopher J. OttiD· 1 shared Eric M. BilottaiD· 1 shared Joshua N. AsiabaniD· 1 shared Karen MilleriD· 1 shared Leopold Garnar-WortzeliD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Chitra SubramanianORCID

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2 papers

Recent·Most cited

MicrobiologyBiochemistryPeer-reviewedJun 10, 2025

Isoleucine binding and regulation of Escherichia coli and Staphylococcus aureus threonine dehydratase (IlvA)

Mi‐Kyung Yun, Chitra Subramanian, Karen Miller…·Charles O. Rock

This study compares isoleucine regulation of IlvA in Escherichia coli and Staphylococcus aureus, revealing structural differences in their regulatory domains and feedback mechanisms.

7 citations

E. colimouse

𝕏 PostBluesky

Molecular BiologyNature Chemical BiologyPeer-reviewedMay 1, 2023

Metabolic adaptations underpin resistance to histone acetyltransferase inhibition

Timothy R. Bishop, Chitra Subramanian, Eric M. Bilotta…·Michael A. Erb

This study identifies CoA metabolism dysregulation as a mechanism of resistance to HAT inhibitors in AML, revealing a potential class-wide vulnerability for anti-cancer therapies targeting HATs.

39 citations

humanbulk RNA-seq

𝕏 PostBluesky