Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myeloma
Natalie J. Tatum, Rebecca Scott, Gina M. Doody, Ian Hickson, Claire Jennings, Mathew P. Martin, Reuben M. Tooze, Julie A. Tucker, Anita Wittner, Lan-Zhen Wang, Eleanor K. Wright, Stephen R. Wedge, Martin E. M. Noble
The paper analyzes IRF4 DNA-binding domain mutations in multiple myeloma, finding they affect DNA-binding kinetics and thermal stability but not affinity, and may confer improved prognosis.
bioRxiv · Mar 12, 2025 · PreprintBiophysics