Reuben M. Tooze

This study shows that enforced MYC expression alters transcriptional programs and metabolic shifts during human plasma cell differentiation without causing transformation.

The paper analyzes IRF4 DNA-binding domain mutations in multiple myeloma, finding they affect DNA-binding kinetics and thermal stability but not affinity, and may confer improved prognosis.

The paper uses cisREAD to integrate chromatin accessibility and gene expression data from B cell differentiation, showing a shift from PU.1/SPIB to AP-1 driven gene regulation during activation.

The paper defines common gene co-expression principles across cancers to improve molecular stratification by identifying consistent expression modules and their associations with mutation states.