Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling
Buwei Huang, Mohamad H. Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Rong Wang, Thomas Schlichthaerle, Jason Z. Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam M. Chazin-Gray, Sidney Chan, Stacey Gerben, A G Murray, , David A. Baker
The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.
bioRxiv · Aug 19, 2023 · PreprintSynthetic Biology