P53 is not necessary for DUX4 pathology
Darko Bosnakovski, Micah D. Gearhart, Erik A. Toso, Olivia O. Recht, Anja Cucak, Abhinav K. Jain, Michelle Craig Barton, Michael Kyba
This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.
Disease Models & Mechanisms · Jan 1, 2017Peer-reviewedGenetics