Micah D. Gearhart

Hepatocyte nuclear factor-1β recruits the nucleosome remodeling and deacetylase complex to activate gene transcription

This study identifies HNF-1β's role in recruiting the NuRD complex to activate gene transcription through chromatin remodeling and acetylation.

Translation of a small upstream open reading frame functions as a rheostat for the regulation of lin-41 by the Let-7 microRNA in Caenorhabditis elegans

The paper identifies a uORF in the lin-41 5'UTR that modulates Let-7 microRNA regulation of lin-41 translation in C. elegans.

Pichinde virus models intrauterine infection by hemorrhagic fever-causing arenaviruses

This study uses Pichinde virus to model arenavirus infection during pregnancy, showing placental infection and fetal demise while highlighting antiviral responses.

The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos

The paper identifies SPN-4 as a specificity factor for CCR4-NOT-dependent clearance of maternal mRNAs in C. elegans embryos, showing its role in targeting specific transcripts for decay.

Spatial Transcriptomics Reveals that the Local Immune Response to Placental Guinea Pig Cytomegalovirus Infection is Driven by Chemokine Signaling

This study uses spatial transcriptomics to show that GPCMV infection disrupts placental function by altering chemokine signaling and antiviral defense in specific regions.

A sperm-oocyte protein partnership required for egg activation in Caenorhabditis elegans

This study identifies a sperm-oocyte protein complex, SPE-11 and OOPS-1, essential for meiotic completion, polyspermy block, and eggshell formation in C. elegans.

Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

This study shows BCOR is essential for syncytiotrophoblast differentiation in mice and humans by repressing stem cell genes and alternate lineage factors.

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.

Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.

Regulation of stem cell identity by miR-200a during spinal cord regeneration

The paper shows that miR-200a regulates mesodermal cell fate during spinal cord regeneration by repressing brachyury expression in axolotls.

Insights into the involvement of spliceosomal mutations in myelodysplastic disorders from an analysis of SACY-1/DDX41 in Caenorhabditis elegans

This study investigates the role of DDX41 mutations in myelodysplastic syndromes using C. elegans SACY-1, revealing antimorphic activity and transcriptome changes through splicing-dependent and -independent mechanisms.

P53 is not necessary for DUX4 pathology

This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.