Darko Bosnakovski

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.

This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.