Michael Kyba

Cardiac Development Long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis

The paper identifies CARDEL as a long non-coding RNA involved in human cardiac specification and homeostasis through in vitro differentiation and gene expression analysis.

The homeobox transcription factor DUXBL controls exit from totipotency

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

B-1 lymphoid cells develop independently of Notch signaling during mouse embryonic development.

This study shows that Notch signaling is not required for B-1 cell development from mouse embryonic stem cells but is needed for B-2 cell emergence.

A novel algorithm for the collective integration of single cell RNA-seq during embryogenesis

This paper introduces a novel algorithm to integrate heterogeneous temporal scRNA-seq datasets and reconstruct lineage trajectories, identifying Ebf1 as a key transcription factor for mouse endothelial development.

P53 is not necessary for DUX4 pathology

This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.