Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells
Tu Dang, Alexandra Roman, Anja Zimmer, Mikhail Y. Lebedin, Ella Bahry, Claudia Marti Grifol, Markus Esser, Seren Sevim-Wunderlich, Duncan C. Miller, Sebastian Diecke, Ralf Kuehn
The paper introduces REPLACE, a CRISPR/Cas9-based method for homology-independent sequence replacement in non-dividing cells, achieving efficient gene and exon editing in primary cells and post-mitotic cardiomyocytes.
bioRxiv · Jul 24, 2026 · PreprintGenomics