Stefan Aigner

Tau is an m6A-associated RNA binding protein that causes RNA dysregulation in disease

The paper identifies tau as an m6A-associated RNA binding protein that causes RNA dysregulation in MAPT coding-variant patients and V337M iNeurons.

Dosage-sensitive RBFOX2 autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome

This study shows that RBFOX2 autoregulation is critical for cardiomyocyte differentiation by maturing the transcriptome, and its disruption leads to congenital heart disease.

A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies

This study identifies splice-switching antisense oligonucleotides that correct splicing defects in SCN8A, reducing seizures and improving survival in a mouse model of genetic epilepsy.

Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43

This paper generates monoclonal antibodies and intrabodies that selectively target misfolded TDP-43 aggregates in disease, showing they inhibit transmission and promote degradation in cell models.

Stress Granules Underlie Acute Myeloid Leukemia Stem Cell Survival and Stress Adaptation

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

Transcriptome Regulation by PARP13 in Basal and Antiviral States in Human Cells

This study investigates PARP13's role in transcriptome regulation during basal and antiviral states, finding it shifts target localization but not binding preferences and supports ISGylation-related gene expression.

Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings

This paper tests cleaning solutions for sentinel cards to improve temporal resolution of SARS-CoV-2 monitoring in schools by distinguishing new infections from persistent viral traces.

Transcriptome-wide profiles of circular RNA and RNA binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

The paper identifies circRNA-RBP interactions in cancer, showing their role in circRNA biogenesis and cancer gene expression, with implications for bladder cancer prognosis.

A Large-Scale Binding and Functional Map of Human RNA Binding Proteins

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.

Context-dependent functional compensation between Ythdf m6A readers

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.

Pyruvate Kinase M Links Glucose Availability to Protein Synthesis

The paper shows that PKM inhibits translation of 7% of the transcriptome under high glucose and pyruvate conditions by stalling ribosome elongation, linking glycolysis to protein synthesis and cell cycle regulation.

Reversal of molecular pathology by RNA-targeting Cas9 in a myotonic dystrophy mouse model

RNA-targeting Cas9 reverses molecular pathology in a myotonic dystrophy mouse model by eliminating toxic CUG RNA and restoring normal cellular functions.