STRUCTURAL PLASTICITY ALLOWS DOUBLECORTIN AND DRUG-STABILIZED MICROTUBULES TO ACCOMMODATE EACH OTHER
Varun Ramaswamy, Szymon W Manka, Darsh D Sharma, Anna Akhmanova, Ankit Rai, Carolyn Moores
This study shows that taxane-stabilized microtubules can adopt 15-protofilament structures, which DCX can bind through conformational remodeling, contrasting with the rigid GMPCPP-stabilized lattice.
bioRxiv · Nov 4, 2026 · PreprintBiophysics